split-banner-image

BIG 1-98

Closed

BIG 1-98/IBCSG 18-98: Adjuvant Letrozole

BCT Study Chair:

Jacquie Chirgwin

A phase III study to evaluate Letrozole as adjuvant endocrine therapy for postmenopausal women with receptor (ER and/or PgR) positive tumours.

international

5526

INTERNATIONAL

Total number of trial

participants internationally

australia & new zealand

667

AUSTRALIA & NEW ZEALAND

Total number of trial participants

in Australia and New Zealand

institutions

29

INSTITUTIONS

Total number of participating institutions

in Australia and New Zealand

BIG 1-98 PUBLICATIONS

2024

Effect of obesity in premenopausal ER+ early breast cancer: EBCTCG data on 80,000 patients in 70 trials.

Pan H, Gray R, on behalf of the EBCTCG. Journal of Clinical Oncology. 2024; 32:5s(SABCS 2024), [Abstract Number SESS-1911; GS2-09], Abstract

Reductions in recurrence in women with early breast cancer entering clinical trials between 1990 and 2009: a pooled analysis of 155 746 women in 151 trials.

Early Breast Cancer Trialists’ Collaborative Group. The Lancet. 2024; 4041407-18, epub 12 October 2024, E-pub

2022

Historical early treatment effects of adjuvant endocrine therapy for breast cancer in high-risk subgroups: Reanalysis of BIG 1-98, SOFT and TEXT.

Regan MM, Niman SM, Fleming GF, Walley B, Viale G, Thurlimann BJK, Loi S, Colleoni M, Pagani O, Francis PA. Journal of Clinical Oncology. 2022; 40(16 suppl):ASCO Abstract #508, Abstract

2020

Clinical behavior of recurrent hormone receptor-positive breast cancer by adjuvant endocrine therapy within the Breast International Group 1-98 Clinical Trial.

Leone JP, Cole BF, Regan MM, Thurlimann B, Coates AS, Rabaglio M, Giobbie-Hurder A, Gelber RD, Ejlertsen B, Harvey VJ, Neven P, Lang I, Bonnefoi H, Wardley An, Goldhirsch A, Di Leo A, Colleoni M, Vaz-Luis I, Lin NU. Cancer. 2020; epub 08 December 2020 E-pub

Cumulative incidence of cardiovascular events under tamoxifen and letrozole alone and in sequence: a report from the BIG 1-98 trial.

Rabaglio M, Sun Z, Maibach R, Giobbie-Hurder A, Ejlertsen B, Harvey VJ, Neven P, Láng I, Bonnefoi H, Wardley A, Ruepp B, Castiglione M, Coates AS, Gelber RD, Goldhirsch A, Colleoni M, Thürlimann B, Regan MM. Breast Cancer Research and Treatment. 2020; 07 Nov 2020. epub ahead of print:doi: 10.1007/s10549-020-05981-z., E-pub

Identifying oncogenic drivers associated with increased risk of late distant recurrence in post-menopausal, estrogen receptor-positive, HER2-negative early breast cancer: results from the BIG 1-98 study.

Luen SJ, Asher R, Lee CK, Savas P, Kammler R, Dell’Orto P, Biasi M, Demanse D, Hackl W, Thurlimann B, Viale G, Di Leo A, Colleoni M, Regan* MM, Loi* S (*Co-last authors). Annals of Oncology. 2020; epub 8 July 2020https://doi.org/10.1016/j.annonc.2020.06.024, E-pub

LOAD MORE

Institutions